Nobel Laureate in Physiology or Medicine Dr Randy Schekman Explains Secretion of Large Particles and miRNA at HKUST 25th Anniversary Distinguished Speakers Series
Dr Schekman described a pathway that mediates secretion of specific microRNAs through exosomes. Exosomes are cell-derived vesicles and are implicated to play key roles in processes such as the creation of a pre-metastatic niche in the spread of tumor cells. Dr Schekman showed a biochemical approach to isolate a unique exosome species and identify specific microRNAs including miR-223 that are enriched in the isolated exsomes. Dr Schekman further described the underlying molecular mechanisms that regulate packaging of miR-223 into exosomes.