HKU Discovers Potential Treatments for Zika Virus Infection-Associated Complications

An abundant amount of Zika virus antigens was found in the testis of a mouse without interferon treatment. Photo from Li Ka Shing Faculty of Medicine, The University of Hong Kong.

Researchers from HKU established a new animal model for studying the pathogenesis, treatments and vaccines for Zika virus. The team led by Professor Yuen Kwok-yung, Dr Jasper Chan Fuk-woo and Dr Anna Zhang Jinxia found that immunosuppressed mice developed disseminated infection and inflammation in multiple organs, including the testis. The mice were effectively treated by recombinant type 1 interferons. The work has been published in EBioMedicine.

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.  http://www.ebiomedicine.com/article/S2352-3964(16)30521-7/

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