Cyagen Biosciences


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Headquartered in Santa Clara, California, with branches in Germany and China, Cyagen Biosciences Inc. is a 300-employee contract research organization that is currently the world’s largest provider of custom-made mouse and rat models. Cyagen is also a leading provider of vector construction and virus packaging services through its interactive platform Additionally, Cyagen offers a comprehensive series of stem cell products including cell lines and media.

1. Generation of custom genetically-modified rodent models. As a leader in custom rodent models, Cyagen offers a “one-stop shop” tailored to your gene research needs. Our services range from DNA vector construction to embryonic stem cell manipulation, microinjection and breeding. Cyagen has also developed and validated animal models using engineered nuclease technology, which allows for the generation of knockout models at reduced cost and turnaround when compared to traditional ES cell-based gene targeting. This investment has led to significant time and cost savings for our clients.

2. Tailor-made DNA vectors and research-use virus. Cyagen can construct almost any type of DNA vectors to meet your research needs. Our revolutionary VectorBuilder platform allows researchers to custom design and order their own vector online. In 2013, we expanded our service portfolio by launching BAC recombineering and virus packaging services. Cyagen packages virus in two dedicated, independent Class 10,000 ultra-clean virus packaging rooms equipped with Biosafety Level 2 (BSL-2) cabinets and incubators.

3. Research-use stem cells and related culture reagents. Cyagen boasts a comprehensive portfolio of research-use stem cell lines, including embryonic stems cells and multiple lineage of somatic stem cells derived from various species. We also provide a variety of supplementing culture and differentiation media to support the growth and maintenance of these cells. Our products have been widely cited in high-impact journals, including Nature and PNAS.

To date, Cyagen has generated many thousands of custom knockout, knockin and transgenic rodent lines while working with over 500 universities and companies worldwide.

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