GLP-1 (Glucagon Like Peptide-1) is a transcriptional product of proglucagon gene as same as glucagon and one of gastrointestinal hormone secreted from L cells of lower section of the small intestine. GLP-1 (7-36) amide and GLP-1 (7-37) are active form and these peptides are digested in blood by DDP4 (dipeptidyl peptidase-4) into GLP-1 (9-36) amide and GLP-1 (9-37), making these peptides lose their activities in a short period.
GLP-1 is known as incretin as same as GIP (Glucose-dependent Insulinotropic Polypeptide), it promotes secretion of insulin from β cells of the isles of Langerhans in the pancreas as glucose dependently. GLP-1 also suppresses secretion of glucagon from α cell of pancreas and concentration of glucose in blood after meal. Drug of type 2 diabetes has been developed by utilizing the functional mechanism of GLP-1 including blood sugar control through pancreas, delayed gastric emptying and appetite suppression which contributes weight loss as extra-pancreatic effects.
ELISA kits for GLP-1
GLP-1, Active form (High sensitivity) Assay Kit
GLP-1, Active form Assay Kit
GLP-1 (9-36/37) Assay Kit