Neuroscience Antibodies Promotion

Genscript

HK$400 for any 40µg Neuroscience Antibodies from GenScript

GenScript offers a wide selection of neuroscience antibodies for Alzheimer’s disease research as well as pathways that may play a role in Parkinson’s disease, and amyotrophic lateral sclerosis.

  • Unique collection of phospho-specific antibodies and their non-phospho pairs
  • Full coverage of neurological disease pathways
  • Multiple applications: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, etc

Terms and conditions:
1. The promotion is valid for HK & Macau customers until 12-May-2017
2. Use promotion code 2017NEURO40 when placing order with ATCG
3. Buy 3 antibodies to waive the shipping fee

Beta-Amyloid Tau Protein APP
GSK3 β-Secretase Catenins
γ-Secretase Synuclein Neuronal Markers

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42

4738_ext_08_en_2_L

Amyloid β-protein (Aβ42) oligomerization is an early event in Alzheimer’s disease (AD). Current diagnostic methods using sequence-specific antibodies against less toxic fibrillar and monomeric Aβ42 run the risk of overdiagnosis. Hence, conformation-specific antibodies against neurotoxic Aβ42 oligomers have garnered much attention for developing more accurate diagnostics. Antibody 24B3, highly specific for the toxic Aβ42 conformer that has a turn at Glu22 and Asp23, recognizes a putative Aβ42 dimer, which forms stable and neurotoxic oligomers more potently than the monomer. 24B3 significantly rescues Aβ42-induced neurotoxicity, whereas sequence-specific antibodies such as 4G8 and 82E1, which recognizes the N-terminus, do not. The ratio of toxic to total Aβ42 in the cerebrospinal fluid of AD patients is significantly higher than in control subjects as measured by sandwich ELISA using antibodies 24B3 and 82E1. Thus, 24B3 may be useful for AD diagnosis and therapy.

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis. Murakami K et al. Sci Rep. 2016 Jul 4;6:29038 PMID: 27374357

#27709 Human Amyloidβ Toxic Oligomer Assay Kit – IBL is developed using the antibody (clone: 24B3) specifically detects a toxic Amyloid Beta conformer. It measures selectively putative Amyloid Beta Oligomer in CSF.

IBL – Aging / Neurodegenrative  
https://www.ibl-japan.co.jp/en/aging_neurodenerative/

IBL – New Company Info
https://www.ibl-japan.co.jp/files/user/pdf/en/company-profile.pdf