Therapeutic ANGPTL2 suppression could antagonize development of heart failure
The research group led by Professor Yuichi Oike at Kumamoto University reported that expression of angiopoietin-like protein 2 (ANGPTL2) increases in pathologically-remodeled hearts of mice and humans, while decreased cardiac ANGPTL2 expression occurs in physiological cardiac remodelling induced by endurance training in mice. Mice overexpressing ANGPTL2 in heart show cardiac dysfunction caused by both inactivation …
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