Rapid isolation of untouched neurons

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Using our Neuron Isolation Kit, you can now rapidly isolate viable and pure neurons from both neonatal and adult mouse brain by depletion of non-neuronal cells. The high purity of the isolated neurons relies on the specificity of the non-neuronal cell surface marker used in the Neuron Isolation kit.

Download this free scientific poster today and see scientific data about the expression of the non-neuronal cell marker:

  • In different neural cell types
  • At different mouse brain regions
  • During different developmental stages (from E14 to P7)

DOWNLOAD THE FREE POSTER

New mGlu Receptor Agonists and Antagonists

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Tocris’s new selection of mGlu receptor ligands.

Key Features of (±)-ADX 71743

  • Negative allosteric modulator at mGlu7
  • Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices
  • Increases evoked excitatory postsynaptic currents (eEPSCs) in mice
  • Brain penetrant

Please click on the product names below to view activity data, references and purity information.

Cat. No. Product Name Description
5377 VU 0483605 Positive allosteric modulator at mGlu1
5613 AZD 9272 Potent and selective mGlu5 antagonist
5614 AZD 2066 mGlu5 antagonist; brain penetrant
5693 VU 0409551 Selective mGlu5 positive allosteric modulator
5715 (±)-ADX 71743 Potent and selective NAM at mGlu7 receptors

View our full range of mGlu receptor ligands.

Neuroscience Antibodies Promotion

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HK$400 for any 40µg Neuroscience Antibodies from GenScript

GenScript offers a wide selection of neuroscience antibodies for Alzheimer’s disease research as well as pathways that may play a role in Parkinson’s disease, and amyotrophic lateral sclerosis.

  • Unique collection of phospho-specific antibodies and their non-phospho pairs
  • Full coverage of neurological disease pathways
  • Multiple applications: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, etc

Terms and conditions:
1. The promotion is valid for HK & Macau customers until 12-May-2017
2. Use promotion code 2017NEURO40 when placing order with ATCG
3. Buy 3 antibodies to waive the shipping fee

Beta-Amyloid Tau Protein APP
GSK3 β-Secretase Catenins
γ-Secretase Synuclein Neuronal Markers

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42

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Amyloid β-protein (Aβ42) oligomerization is an early event in Alzheimer’s disease (AD). Current diagnostic methods using sequence-specific antibodies against less toxic fibrillar and monomeric Aβ42 run the risk of overdiagnosis. Hence, conformation-specific antibodies against neurotoxic Aβ42 oligomers have garnered much attention for developing more accurate diagnostics. Antibody 24B3, highly specific for the toxic Aβ42 conformer that has a turn at Glu22 and Asp23, recognizes a putative Aβ42 dimer, which forms stable and neurotoxic oligomers more potently than the monomer. 24B3 significantly rescues Aβ42-induced neurotoxicity, whereas sequence-specific antibodies such as 4G8 and 82E1, which recognizes the N-terminus, do not. The ratio of toxic to total Aβ42 in the cerebrospinal fluid of AD patients is significantly higher than in control subjects as measured by sandwich ELISA using antibodies 24B3 and 82E1. Thus, 24B3 may be useful for AD diagnosis and therapy.

Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis. Murakami K et al. Sci Rep. 2016 Jul 4;6:29038 PMID: 27374357

#27709 Human Amyloidβ Toxic Oligomer Assay Kit – IBL is developed using the antibody (clone: 24B3) specifically detects a toxic Amyloid Beta conformer. It measures selectively putative Amyloid Beta Oligomer in CSF.

HKUST Researchers Find Phase Transition in Postsynaptic Densities

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A research team led by Prof Mingjie Zhang at HKUST, has achieved a breakthrough that provides mechanistic insights into the causes that lead to various neuropsychiatric disorders such as autism, intellectual disorders and schizophrenia. Their studies of the SynGAP/PSD-95 complex formation unexpectedly found physical phase transition in synaptic signaling activity of neurons. The research findings were published in Cell on August 25, 2016.

http://www.ust.hk/about-hkust/media-relations/press-releases/hkust-researchers-find-possible-mechanisms-human-brain-disorders-may-shed-light-new-treatments-2/

Original Article: Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity. Source: http://www.cell.com/cell/abstract/S0092-8674(16)30914-X

Science stars of China – Nancy IP

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From ancient DNA to neutrinos and neuroscience, top researchers in China are making big impacts — and raising their country’s standing in science.

NANCY IP: A neuroscientist explores the brain through basic research and translational medicine.

http://www.nature.com/news/science-stars-of-china-1.20113#/Nancy_Ip

Breakthrough Discoveries at HKUST Offer New Hope for Treatment of Alzheimer’s Disease

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A research team led by Prof Nancy Ip of HKUST found that interleukin-33 (IL-33) ameliorates cognitive decline and Alzheimer’s disease-like pathology. The groundbreaking study has just been published in PNAS.

Defects in the removal of Aβ protein in the brain are believed to be one of the major causes underlying AD. The team at HKUST showed that the presence of IL-33 mobilized the immune cells of the brain, the microglia, to the amyloid plaques and promoted the clearance of Aβ protein. IL-33 also triggered changes in the microglia to reduce overall inflammation in the brain. Inflammation contributes to and drives the pathology of the disease.

“These exciting findings bring us one step closer to understanding the pathological process of this complex, multi-factorial disease and provide a new avenue for developing AD treatments,” said Prof Ip. “The next step will be to translate the findings from the mouse study into clinical treatments for humans.”

http://www.ust.hk/about-hkust/media-relations/press-releases/breakthrough-discoveries-hkust-offer-new-hope-treatment-alzheimers-disease-2/

Amy K. Y. Fu, Kwok-Wang Hung, Michael Y. F. Yuen, Xiaopu Zhou, Deejay S. Y. Mak, Ivy C. W. Chan, Tom H. Cheung, Baorong Zhang, Wing-Yu Fu, Foo Y. Liew, and Nancy Y. Ip. (2016) IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline. Proc Natl Acad Sci USA doi: 10.1073/pnas.1604032113.

http://www.pnas.org/content/early/2016/04/13/1604032113