New mGlu Receptor Agonists and Antagonists

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Tocris’s new selection of mGlu receptor ligands.

Key Features of (±)-ADX 71743

  • Negative allosteric modulator at mGlu7
  • Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices
  • Increases evoked excitatory postsynaptic currents (eEPSCs) in mice
  • Brain penetrant

Please click on the product names below to view activity data, references and purity information.

Cat. No. Product Name Description
5377 VU 0483605 Positive allosteric modulator at mGlu1
5613 AZD 9272 Potent and selective mGlu5 antagonist
5614 AZD 2066 mGlu5 antagonist; brain penetrant
5693 VU 0409551 Selective mGlu5 positive allosteric modulator
5715 (±)-ADX 71743 Potent and selective NAM at mGlu7 receptors

View our full range of mGlu receptor ligands.

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