Mac-2 binding protein (Mac-2bp), known as 90K, is a highly N-glycosylated, secreted protein, identified as a ligand of Galectin-3. It is considered that through interaction with Galectin-3, Mac-2bp promotes homotypic cell-cell contact or regulates cell adhesion. And it has been reported that Mac-2bp levels in blood have associations with various cancers and chronic hepatic diseases such as NASH (Non-Alcoholic Steatohepatitis).
Hepatocyte growth factor/scatter factor (HGF) is a liver regeneration and growth factor that was isolated and purified from the plasma of the person who suffers fulminant hepatitis. In addition blood and tissue concentrations being assessed during liver injury, increases in concentration in body fluids have been reported in other types of disease besides liver disease (e.g., inflammatory diseases, neoplastic diseases, and fibrosis). HGF is secreted as an inactive single-chain pro-form, and it exerts its physiological activity after processing by HGF activator (HGFA), coagulation factor VIIa, etc., and conversion to activated HGF, a heterodimer. This product is a kit that measures human HGF by the WHO standard.
c-Met, the product of c-met gene has been reported to be the HGF receptor since HGF induces phosphorylation of c-Met by binding specifically to it. It is a heterodimer protein composed of an α-chain that is linked to a β-chain. The β-chain has the intracellular tyrosine kinase domain, the transmembrane domain and the extracellular domain, and it is tied into the α-chain that is the extracellular domain of c-Met. c-Met exists mainly in epidermal cells. It is found in the digestive tract, prostate gland, seminal vesicles, mammary gland, microglia cells, monocytes and macrophages, and more amount in the liver and kidney. It is considered that c-Met tansmits signals resulting from binding to HGF, such as growth, motility and organ formation, in the organs and cells mentioned above. This kit is designed to measure Human c-Met.