Uncategorized

Product News, Uncategorized

Monoclonal Anti-mouse pDC/IPC/CD317/BST2 (clone 120G8.04)

Dendritics generated rat monoclonal antibody (mAb) that recognizes mouse plasmacytoid dendritic cells (pDCs). The target molecule was found to be BST2 (bone marrow stromal cell antigen 2). This antibody, named 120G8, stains a small subset of CD11c-low spleen cells with high specificity. This population produces high amounts of IFNα upon in vitro viral stimulation. Both ex vivo- and in vitro-derived 120G8+ cells display a phenotype identical with that of mouse pDCs (B220-high Ly6C-high Gr1-low CD11b- CD11c-low). Mice treated with 120G8 mAb are depleted of B220-high Ly6C-high CD11c-low cells and have a much reduced ability to produce IFNα in response to in vivo CpG stimulation. mAb 120G8 stains all and only B220-high Ly6C-high CD11c-low pDC in all lymphoid organs. Immunohistochemical studies performed with this mAb indicate that pDC arelocated in the T cell area of spleen, lymph nodes, and Peyer’s patches. Using 120G8 mAb in immunofluorescence studies demonstrates mouse strain- and organ-specific differences in the frequency of pDCs and other DC subsets (Asselin-Paturel C et al, 2003 ; J. Immunol., 172:6466; Blasius AI, 2006, J. Immunol., 177:3260 ; Goubier A et Al, 2008, Immunity, 29:464-475). Clone: 120G8Species: ratSpecificity: mouse pDCs/IFN producing cells (IPC) (extracellular domain)Immunogen: mouse plasmatocytoid DCs (pDCs)Isotype: IgG1/kappaSpecies cross-reactivity: ndApplications tested: Flow cytometry, in vivo depletion, IHCUsage recommendation: This monoclonal antibody may be used between at 1-10 µg/ml. For pDCs in vivo depletion in Balb /c mice, mAb 120G8 was used between 50-200 µg /injection. http://www.dendritics.net/products/detail/ddx0390-120g8.04  

Uncategorized

防伪, 较真就要[一]码归一[码] R&D Systems, Tocris Bioscience, Novus Biologicals

科研中,大家对假货和以次充好深恶痛觉,因为假货不但造成可观的经济损失,导致的错误结果更可能让整个课题走上岔路。 对于知名品牌,假货就是潜伏在身后影子里的幽灵,品牌越高大,更长的影子也招来更多的幽灵。保障用户权利,驱散这些幽灵,Bio-Techne 和 ATCG 责无旁贷! 这次,我们给 R&D Systems ,Tocris Bioscience 和 Novus Biologicals 全线产品添加防伪码,让假货露出原形! 在新包装中,你可以找到 Bio-Techne 特色的重溶指南贴纸,防伪码就藏在这里的右下角: 刮开涂层,左侧的二维码一览无余,同时右侧的 16 位数字防伪码也完整呈现: 具体鉴别流程如下: 第一步 关注 R&D Systems 公众号并进入 第二步 从「购买与防伪」菜单进入「防伪查询」 第三步 点击「扫一扫 查真伪」扫描刚刮开的二维码 查询结果 根据返回的结果,您就可以确认是不是正品了: 发现假货,请立即通过技术支持电话向我们反馈,举报有奖 技术支持热线(工作日 8:30-17:30) 800-988-1270 400-821-347 好啦,了解了防伪码,认识了新包装,让科研更轻松,让生活更有乐趣!R&D Systems ,Tocris Bioscience 和 Novus Biologicals 的新包装产品,已经整装待发喽!

Uncategorized

Liver Diseases

Mac-2 binding protein (Mac-2bp), known as 90K, is a highly N-glycosylated, secreted protein, identified as a ligand of Galectin-3. It is considered that through interaction with Galectin-3, Mac-2bp promotes homotypic cell-cell contact or regulates cell adhesion. And it has been reported that Mac-2bp levels in blood have associations with various cancers and chronic hepatic diseases such as NASH (Non-Alcoholic Steatohepatitis). 27362 Human Mac-2 binding protein (Mac-2bp) Assay Kit – IBL 27796 Mouse Mac-2 binding protein (Mac-2bp) Assay Kit – IBL Hepatocyte growth factor/scatter factor (HGF) is a liver regeneration and growth factor that was isolated and purified from the plasma of the person who suffers fulminant hepatitis. In addition blood and tissue concentrations being assessed during liver injury, increases in concentration in body fluids have been reported in other types of disease besides liver disease (e.g., inflammatory diseases, neoplastic diseases, and fibrosis). HGF is secreted as an inactive single-chain pro-form, and it exerts its physiological activity after processing by HGF activator (HGFA), coagulation factor VIIa, etc., and conversion to activated HGF, a heterodimer. This product is a kit that measures human HGF by the WHO standard. 27402 Human Total HGF Assay Kit c-Met, the product of c-met gene has been reported to be the HGF receptor since HGF induces phosphorylation of c-Met by binding specifically to it. It is a heterodimer protein composed of an α-chain that is linked to a β-chain. The β-chain has the intracellular tyrosine kinase domain, the transmembrane domain and the extracellular domain, and it is tied into the α-chain that is the extracellular domain of c-Met. c-Met exists mainly in epidermal cells. It is found in the digestive tract, prostate gland, seminal vesicles, mammary gland, microglia cells, monocytes and macrophages, and more amount in the liver and kidney. It is considered that c-Met tansmits signals resulting from binding to HGF, such as growth, motility and organ formation, in the organs and cells mentioned above. This kit is designed to measure Human c-Met. 27407 Human c-Met Assay Kit

Uncategorized

Buy Antibodies Get Rewards

Terms & Conditions Buy 1 antibody to redeem HKD50 credit, 2 antibodies to redeem HKD150 credit, and 3 antibodies to redeem HKD300 credit. Valid for R&D Systems antibodies from 100ug / 100ul / 100test or larger sizes. Valid until 28/6/2017. Promotion not valid in conjunction with other offers or discounts. Promotion valid for single order only and cannot be accumulated. ATCG reserves the right to explain the terms of this promotion.  

Scroll to Top